Version 5.4
| Homo sapiens Protein: LRRC52 | |||||
|---|---|---|---|---|---|
| Summary | |||||
| InnateDB Protein | IDBP-104470.6 | ||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
| Gene Symbol | LRRC52 | ||||
| Protein Name | leucine rich repeat containing 52 | ||||
| Synonyms | |||||
| Species | Homo sapiens | ||||
| Ensembl Protein | ENSP00000294818 | ||||
| InnateDB Gene | IDBG-104468 (LRRC52) | ||||
| Protein Structure |
|
||||
| UniProt Annotation | |||||
| Function | Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. KCNU1 channel auxiliary protein. May modulate KCNU1 gating properties. {ECO:0000269PubMed:22547800, ECO:0000269PubMed:23129643}. | ||||
| Subcellular Localization | Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Expression at the cell surface may require the presence of KCNU1. | ||||
| Disease Associations | |||||
| Tissue Specificity | Mainly expressed in testis and skeletal muscle. {ECO:0000269PubMed:22547800}. | ||||
| Comments | |||||
| Interactions | |||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
||||
| Gene Ontology | |||||
Molecular Function |
|
||||
| Biological Process |
|
||||
| Cellular Component |
|
||||
| Protein Structure and Domains | |||||
| PDB ID | |||||
| InterPro |
IPR000372
Leucine-rich repeat-containing N-terminal IPR001611 Leucine-rich repeat IPR003591 Leucine-rich repeat, typical subtype |
||||
| PFAM |
PF01462
PF00560 PF13504 PF13855 |
||||
| PRINTS | |||||
| PIRSF | |||||
| SMART |
SM00013
SM00369 |
||||
| TIGRFAMs | |||||
| Post-translational Modifications | |||||
| Modification | |||||
| Cross-References | |||||
| SwissProt | Q8N7C0 | ||||
| PhosphoSite | PhosphoSite- | ||||
| TrEMBL | |||||
| UniProt Splice Variant | |||||
| Entrez Gene | 440699 | ||||
| UniGene | Hs.664975 | ||||
| RefSeq | NP_001005214 | ||||
| HUGO | HGNC:32156 | ||||
| OMIM | 615218 | ||||
| CCDS | CCDS30930 | ||||
| HPRD | 13396 | ||||
| IMGT | |||||
| EMBL | AK098677 AL157714 BC132981 BC132983 | ||||
| GenPept | AAI32982 AAI32984 BAC05375 CAI15338 | ||||