InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UCK2

Summary

InnateDB Protein

IDBP-104494.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UCK2

Protein Name

uridine-cytidine kinase 2

Synonyms

TSA903; UK; UMPK;

Species

Homo sapiens

Ensembl Protein

ENSP00000356853

InnateDB Gene

IDBG-104492 (UCK2)

Protein Structure

UniProt Annotation

Function

Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine.

Subcellular Localization

Disease Associations

Tissue Specificity

According to PubMed:8812458; testis-specific. According to PubMed:11306702, placenta-specific. {ECO:0000269PubMed:8812458}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004140	dephospho-CoA kinase activity
GO:0004849	uridine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0019206	nucleoside kinase activity

Biological Process

GO:0006206	pyrimidine nucleobase metabolic process
GO:0007631	feeding behavior
GO:0008152	metabolic process
GO:0015937	coenzyme A biosynthetic process
GO:0016310	phosphorylation
GO:0043097	pyrimidine nucleoside salvage
GO:0044206	UMP salvage
GO:0044211	CTP salvage
GO:0044281	small molecule metabolic process
GO:0048678	response to axon injury
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0071453	cellular response to oxygen levels

Cellular Component

GO:0005575	cellular_component
GO:0005829	cytosol
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000764 Uridine kinase like
IPR001977 Dephospho-CoA kinase
IPR006082 Phosphoribulokinase
IPR006083 Phosphoribulokinase/uridine kinase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01121
PF00485

PRINTS

PR00988
PR00478

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BZX2