InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADCY10

Summary

InnateDB Protein

IDBP-104577.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADCY10

Protein Name

adenylate cyclase 10 (soluble)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356822

InnateDB Gene

IDBG-104569 (ADCY10)

Protein Structure

UniProt Annotation

Function

Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation. {ECO:0000269PubMed:15659711, ECO:0000269PubMed:17591988}.

Subcellular Localization

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin.

Disease Associations

Hypercalciuria absorptive 2 (HCA2) [MIM:143870]: A common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis. {ECO:0000269PubMed:11932268}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone. {ECO:0000269PubMed:11932268, ECO:0000269PubMed:15659711, ECO:0000269PubMed:17591988}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004016	adenylate cyclase activity
GO:0005524	ATP binding
GO:0016849	phosphorus-oxygen lyase activity

Biological Process

GO:0006171	cAMP biosynthetic process
GO:0007283	spermatogenesis
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
IPR016577 Adenylate cylcase, type 10
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029787 Nucleotide cyclase

PFAM

PF00211

PRINTS

PIRSF

PIRSF011131

SMART

SM00044

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt