InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: XCL1

Summary

InnateDB Protein

IDBP-104635.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XCL1

Protein Name

chemokine (C motif) ligand 1

Synonyms

ATAC; LPTN; LTN; SCM-1; SCM-1a; SCM1; SCM1A; SCYC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000356792

InnateDB Gene

IDBG-104633 (XCL1)

Protein Structure

UniProt Annotation

Function

Chemotactic activity for lymphocytes but not for monocytes or neutrophils.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0042379	chemokine receptor binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0002725	negative regulation of T cell cytokine production
GO:0002726	positive regulation of T cell cytokine production
GO:0002826	negative regulation of T-helper 1 type immune response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0009615	response to virus
GO:0010820	positive regulation of T cell chemotaxis
GO:0030593	neutrophil chemotaxis
GO:0032689	negative regulation of interferon-gamma production
GO:0032703	negative regulation of interleukin-2 production
GO:0032733	positive regulation of interleukin-10 production
GO:0035782	mature natural killer cell chemotaxis
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050727	regulation of inflammatory response
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0071353	cellular response to interleukin-4
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0071636	positive regulation of transforming growth factor beta production
GO:0071663	positive regulation of granzyme B production
GO:0090023	positive regulation of neutrophil chemotaxis
GO:2000412	positive regulation of thymocyte migration
GO:2000503	positive regulation of natural killer cell chemotaxis
GO:2000513	positive regulation of granzyme A production
GO:2000518	negative regulation of T-helper 1 cell activation
GO:2000538	positive regulation of B cell chemotaxis
GO:2000553	positive regulation of T-helper 2 cell cytokine production
GO:2000556	positive regulation of T-helper 1 cell cytokine production
GO:2000558	positive regulation of immunoglobulin production in mucosal tissue
GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation
GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation
GO:2000566	positive regulation of CD8-positive, alpha-beta T cell proliferation