InnateDB Protein
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IDBP-104638.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DPT
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Protein Name
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dermatopontin
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Synonyms
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TRAMP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000356791
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InnateDB Gene
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IDBG-104636 (DPT)
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Protein Structure
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Function |
Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted, extracellular space, extracellular matrix {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts. {ECO:0000269PubMed:10233760, ECO:0000269PubMed:8104875}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q07507
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PhosphoSite |
PhosphoSite-Q07507
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1805
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UniGene |
Hs.80552
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RefSeq |
NP_001928
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HUGO |
HGNC:3011
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OMIM |
125597
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CCDS |
CCDS1275
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HPRD |
00510
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IMGT |
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EMBL |
AK292596
AL049798
BC033736
CH471067
Z22865
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GenPept |
AAH33736
BAF85285
CAA80487
CAB46693
EAW90830
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