InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SELE

Summary

InnateDB Protein

IDBP-104703.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SELE

Protein Name

selectin E

Synonyms

CD62E; ELAM; ELAM1; ESEL; LECAM2;

Species

Homo sapiens

Ensembl Protein

ENSP00000331736

InnateDB Gene

IDBG-104701 (SELE)

Protein Structure

UniProt Annotation

Function

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. {ECO:0000269PubMed:1689848}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	15 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0033691	sialic acid binding
GO:0043274	phospholipase binding
GO:0070492	oligosaccharide binding

Biological Process

GO:0002092	positive regulation of receptor internalization
GO:0002523	leukocyte migration involved in inflammatory response
GO:0002687	positive regulation of leukocyte migration
GO:0006954	inflammatory response
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007202	activation of phospholipase C activity
GO:0007596	blood coagulation
GO:0019722	calcium-mediated signaling
GO:0030029	actin filament-based process
GO:0032496	response to lipopolysaccharide
GO:0034612	response to tumor necrosis factor
GO:0045087	innate immune response (InnateDB)
GO:0050727	regulation of inflammatory response
GO:0050900	leukocyte migration
GO:0050901	leukocyte tethering or rolling
GO:0070555	response to interleukin-1

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0005905	coated pit
GO:0016021	integral component of membrane
GO:0030863	cortical cytoskeleton
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000436 Sushi/SCR/CCP
IPR000742 Epidermal growth factor-like domain
IPR001304 C-type lectin
IPR002396 Selectin superfamily
IPR013111 EGF-like domain, extracellular
IPR016187 C-type lectin fold

PFAM

PF00084
PF00008
PF00059
PF07974

PRINTS

PR00343

PIRSF

SMART

SM00032
SM00181
SM00034

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt