InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIFAP3

Summary

InnateDB Protein

IDBP-104745.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIFAP3

Protein Name

kinesin-associated protein 3

Synonyms

dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; SMAP; Smg-GDS;

Species

Homo sapiens

Ensembl Protein

ENSP00000354560

InnateDB Gene

IDBG-104737 (KIFAP3)

Protein Structure

UniProt Annotation

Function

Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0019894	kinesin binding

Biological Process

GO:0006461	protein complex assembly
GO:0007017	microtubule-based process
GO:0007018	microtubule-based movement
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0008104	protein localization
GO:0008285	negative regulation of cell proliferation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0043066	negative regulation of apoptotic process
GO:0046587	positive regulation of calcium-dependent cell-cell adhesion
GO:0061024	membrane organization
GO:0072383	plus-end-directed vesicle transport along microtubule

Cellular Component

GO:0000794	condensed nuclear chromosome
GO:0005783	endoplasmic reticulum
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005876	spindle microtubule
GO:0015630	microtubule cytoskeleton
GO:0016939	kinesin II complex
GO:0030990	intraciliary transport particle
GO:0070062	extracellular vesicular exosome