InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FMO3

Summary

InnateDB Protein

IDBP-104770.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FMO3

Protein Name

flavin containing monooxygenase 3

Synonyms

dJ127D3.1; FMOII; TMAU;

Species

Homo sapiens

Ensembl Protein

ENSP00000356729

InnateDB Gene

IDBG-104768 (FMO3)

Protein Structure

UniProt Annotation

Function

Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds.

Subcellular Localization

Microsome membrane. Endoplasmic reticulum membrane.

Disease Associations

Trimethylaminuria (TMAU) [MIM:602079]: Inborn error of metabolism associated with an offensive body odor and caused by deficiency of FMO-mediated N-oxidation of amino-trimethylamine (TMA) derived from foodstuffs. Affected individuals excrete relatively large amounts of TMA in their urine, sweat, and breath, and exhibit a fishy body odor characteristic of the malodorous free amine. {ECO:0000269PubMed:10338091, ECO:0000269PubMed:10479479, ECO:0000269PubMed:11191884, ECO:0000269PubMed:12893987, ECO:0000269PubMed:9536088}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004499	N,N-dimethylaniline monooxygenase activity
GO:0016491	oxidoreductase activity
GO:0016597	amino acid binding
GO:0034899	trimethylamine monooxygenase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0017144	drug metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000960 Flavin monooxygenase FMO
IPR002253 Flavin monooxygenase (FMO) 1
IPR002254 Flavin monooxygenase (FMO) 2
IPR002255 Flavin monooxygenase (FMO) 3
IPR012143 Dimethylaniline monooxygenase, N-oxide-forming
IPR020946 Flavin monooxygenase-like
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF00743
PF07992

PRINTS

PR00370
PR01121
PR01122
PR01123

PIRSF

PIRSF000332

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt