InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FMO2

Summary

InnateDB Protein

IDBP-104780.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FMO2

Protein Name

flavin containing monooxygenase 2 (non-functional)

Synonyms

FMO1B1;

Species

Homo sapiens

Ensembl Protein

ENSP00000209929

InnateDB Gene

IDBG-104776 (FMO2)

Protein Structure

UniProt Annotation

Function

Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive. {ECO:0000269PubMed:9804831}.

Subcellular Localization

Microsome membrane. Endoplasmic reticulum membrane.

Disease Associations

Tissue Specificity

Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain. {ECO:0000269PubMed:11042094, ECO:0000269PubMed:9804831}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0004499	N,N-dimethylaniline monooxygenase activity
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0006082	organic acid metabolic process
GO:0006739	NADP metabolic process
GO:0006805	xenobiotic metabolic process
GO:0009404	toxin metabolic process
GO:0017144	drug metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070995	NADPH oxidation
GO:0072592	oxygen metabolic process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000960 Flavin monooxygenase FMO
IPR002253 Flavin monooxygenase (FMO) 1
IPR002254 Flavin monooxygenase (FMO) 2
IPR002257 Flavin monooxygenase (FMO) 5
IPR020946 Flavin monooxygenase-like
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF00743
PF07992

PRINTS

PR00370
PR01121
PR01122
PR01125

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99518