InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FMO1

Summary

InnateDB Protein

IDBP-104783.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FMO1

Protein Name

flavin containing monooxygenase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356724

InnateDB Gene

IDBG-104781 (FMO1)

Protein Structure

UniProt Annotation

Function

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.

Subcellular Localization

Microsome membrane. Endoplasmic reticulum membrane.

Disease Associations

Tissue Specificity

Expressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0004499	N,N-dimethylaniline monooxygenase activity
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0006082	organic acid metabolic process
GO:0006805	xenobiotic metabolic process
GO:0009404	toxin metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:0070995	NADPH oxidation

Cellular Component

GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000960 Flavin monooxygenase FMO
IPR002253 Flavin monooxygenase (FMO) 1
IPR002254 Flavin monooxygenase (FMO) 2
IPR012143 Dimethylaniline monooxygenase, N-oxide-forming
IPR020946 Flavin monooxygenase-like
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF00743
PF07992

PRINTS

PR00370
PR01121
PR01122

PIRSF

PIRSF000332

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt