InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIGC

Summary

InnateDB Protein

IDBP-104839.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIGC

Protein Name

phosphatidylinositol glycan anchor biosynthesis, class C

Synonyms

GPI2;

Species

Homo sapiens

Ensembl Protein

ENSP00000356702

InnateDB Gene

IDBG-104835 (PIGC)

Protein Structure

UniProt Annotation

Function

Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity

Biological Process

GO:0006501	C-terminal protein lipidation
GO:0006506	GPI anchor biosynthetic process
GO:0016254	preassembly of GPI anchor in ER membrane
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane