InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HOXA9

Summary

InnateDB Protein

IDBP-10492.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOXA9

Protein Name

homeobox A9

Synonyms

ABD-B; HOX1; HOX1.7; HOX1G;

Species

Homo sapiens

Ensembl Protein

ENSP00000343619

InnateDB Gene

IDBG-10490 (HOXA9)

Protein Structure

UniProt Annotation

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. {ECO:0000269PubMed:22269951}.

Subcellular Localization

Nucleus.

Disease Associations

Note=A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98.Note=A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	19 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0042118	endothelial cell activation
GO:0045087	innate immune response (InnateDB)
GO:0045638	negative regulation of myeloid cell differentiation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001356 Homeobox domain
IPR006711 Hox9, N-terminal activation domain
IPR009057 Homeodomain-like
IPR017112 Homeobox protein Hox9
IPR020479 Homeodomain, metazoa

PFAM

PF00046
PF04617

PRINTS

PR00024

PIRSF

PIRSF037109

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References