InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RALGPS2

Summary

InnateDB Protein

IDBP-105070.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RALGPS2

Protein Name

Ral GEF with PH domain and SH3 binding motif 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356607

InnateDB Gene

IDBG-105068 (RALGPS2)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Associates with membranes through the PH domain. {ECO:0000250}.

Disease Associations

Note=RALGPS2 is a potential candidate gene for susceptibility to Alzheimer disease linked to 1q24. {ECO:0000269PubMed:17564960}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001849 Pleckstrin homology domain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR023578 Ras guanine nucleotide exchange factor domain

PFAM

PF00169
PF00617

PRINTS

PIRSF

SMART

SM00233
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q86X27