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InnateDB Protein
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IDBP-105076.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RALGPS2
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Protein Name
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Ral GEF with PH domain and SH3 binding motif 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000313613
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InnateDB Gene
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IDBG-105068 (RALGPS2)
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Protein Structure
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| Function |
Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Associates with membranes through the PH domain. {ECO:0000250}.
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| Disease Associations |
Note=RALGPS2 is a potential candidate gene for susceptibility to Alzheimer disease linked to 1q24. {ECO:0000269PubMed:17564960}.
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
6
[view]
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| Protein-Protein |
6
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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Molecular Function |
| Accession |
GO Term |
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GO:0005085
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guanyl-nucleotide exchange factor activity
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| Biological Process |
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GO:0007264
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small GTPase mediated signal transduction
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR001895
Ras guanine-nucleotide exchange factors catalytic domain
IPR023578
Ras guanine nucleotide exchange factor domain
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| PFAM |
PF00617
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| PRINTS |
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| PIRSF |
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| SMART |
SM00147
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q86X27
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
55103
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| UniGene |
Hs.644008
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| RefSeq |
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| HUGO |
HGNC:30279
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| OMIM |
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| CCDS |
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| HPRD |
15206
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4