InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOAT1

Summary

InnateDB Protein

IDBP-105110.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOAT1

Protein Name

sterol O-acyltransferase 1

Synonyms

ACACT; ACAT; ACAT-1; ACAT1; SOAT; STAT;

Species

Homo sapiens

Ensembl Protein

ENSP00000356591

InnateDB Gene

IDBG-105106 (SOAT1)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:16154994}; Multi-pass membrane protein {ECO:0000269PubMed:16154994}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0004772	sterol O-acyltransferase activity
GO:0005515	protein binding
GO:0015485	cholesterol binding
GO:0034736	cholesterol O-acyltransferase activity

Biological Process

GO:0008203	cholesterol metabolic process
GO:0010742	macrophage derived foam cell differentiation
GO:0010878	cholesterol storage
GO:0033344	cholesterol efflux
GO:0034379	very-low-density lipoprotein particle assembly
GO:0034435	cholesterol esterification
GO:0042632	cholesterol homeostasis
GO:0042986	positive regulation of amyloid precursor protein biosynthetic process