Version 5.4
Homo sapiens Protein: TDRD5
Summary
InnateDB Protein IDBP-105127.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TDRD5
Protein Name tudor domain containing 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000356586
InnateDB Gene IDBG-105125 (TDRD5)
Protein Structure
UniProt Annotation
Function Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Note=Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007286 spermatid development
GO:0030719 P granule organization
GO:0043046 DNA methylation involved in gamete generation
Cellular Component
GO:0033391 chromatoid body
GO:0071546 pi-body
Protein Structure and Domains
PDB ID
InterPro IPR002999 Tudor domain
PFAM PF00567
PRINTS
PIRSF
SMART SM00333
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NAT2
PhosphoSite PhosphoSite-Q8NAT2
TrEMBL A0A024R910
UniProt Splice Variant
Entrez Gene 163589
UniGene Hs.739186
RefSeq NP_001186020
HUGO HGNC:20614
OMIM
CCDS CCDS1332
HPRD 15483
IMGT
EMBL AK092142 AK127370 AL160286 AL590987 BC043368 BC089387 BC130532 BC144058 CH471067
GenPept AAH43368 AAH89387 AAI30533 AAI44059 BAC03815 BAC86946 CAH73723 CAH73724 CAI15400 EAW91052 EAW91053

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca