InnateDB Protein
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IDBP-105131.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TDRD5
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Protein Name
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tudor domain containing 5
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000294848
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InnateDB Gene
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IDBG-105125 (TDRD5)
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Protein Structure
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Function |
Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Note=Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002999
Tudor domain
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PFAM |
PF00567
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PRINTS |
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PIRSF |
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SMART |
SM00333
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NAT2
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PhosphoSite |
PhosphoSite-Q8NAT2
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TrEMBL |
A0A024R910
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UniProt Splice Variant |
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Entrez Gene |
163589
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UniGene |
Hs.739186
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RefSeq |
NP_775804
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HUGO |
HGNC:20614
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OMIM |
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CCDS |
CCDS1332
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HPRD |
15483
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IMGT |
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EMBL |
AK092142
AK127370
AL160286
AL590987
BC043368
BC089387
BC130532
BC144058
CH471067
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GenPept |
AAH43368
AAH89387
AAI30533
AAI44059
BAC03815
BAC86946
CAH73723
CAH73724
CAI15400
EAW91052
EAW91053
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