Version 5.4
Homo sapiens Protein: TOR1AIP2
Summary
InnateDB Protein IDBP-105137.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOR1AIP2
Protein Name torsin A interacting protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000356584
InnateDB Gene IDBG-105135 (TOR1AIP2)
Protein Structure
UniProt Annotation
Function Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity. {ECO:0000269PubMed:19339278, ECO:0000269PubMed:23569223, ECO:0000269PubMed:24275647}.
Subcellular Localization Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001671 ATPase activator activity
GO:0005515 protein binding
GO:0051117 ATPase binding
Biological Process
GO:0007029 endoplasmic reticulum organization
GO:0032781 positive regulation of ATPase activity
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID
InterPro IPR008662 Lamina-associated polypeptide 1C
PFAM PF05609
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NFQ8
PhosphoSite PhosphoSite-Q8NFQ8
TrEMBL A0A024R957
UniProt Splice Variant
Entrez Gene 163590
UniGene Hs.723247
RefSeq NP_659471
HUGO HGNC:24055
OMIM 614513
CCDS CCDS1334
HPRD 10048
IMGT
EMBL AF464140 AL359853 BC101532 BC112225 CH471067
GenPept AAI01533 AAI12226 AAM50514 CAH70382 EAW91059 EAW91060

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca