Version 5.4
Homo sapiens Protein: CEP350
Summary
InnateDB Protein IDBP-105154.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEP350
Protein Name centrosomal protein 350kDa
Synonyms CAP350; GM133;
Species Homo sapiens
Ensembl Protein ENSP00000356579
InnateDB Gene IDBG-105152 (CEP350)
Protein Structure
UniProt Annotation
Function Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. {ECO:0000269PubMed:15615782, ECO:0000269PubMed:16314388, ECO:0000269PubMed:17878239, ECO:0000269PubMed:18412956, ECO:0000269PubMed:19052644}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus. Note=Associated with mitotic spindles. Nuclear, in discrete foci. Associated with intermediate filaments. Also present in the pericentrosomal area.
Disease Associations
Tissue Specificity Detected in heart, brain, skeletal muscle, testis, placenta, lung, liver, kidney and pancreas. {ECO:0000269PubMed:11891061, ECO:0000269PubMed:15615782}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008017 microtubule binding
Biological Process
GO:0034453 microtubule anchoring
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000938 CAP Gly-rich domain
PFAM PF01302
PRINTS
PIRSF
SMART SM01052
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5VT06
PhosphoSite PhosphoSite-Q5VT06
TrEMBL Q5T2X4
UniProt Splice Variant
Entrez Gene 9857
UniGene Hs.700048
RefSeq NP_055625
HUGO HGNC:24238
OMIM
CCDS CCDS1336
HPRD 09870
IMGT
EMBL AF287356 AF387614 AL353708 AL390718 AL590632 AL645487
GenPept AAL55733 AAL91355 CAH72345 CAI14833 CAI15177

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca