Version 5.4
Homo sapiens Protein: XPR1
Summary
InnateDB Protein IDBP-105180.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XPR1
Protein Name xenotropic and polytropic retrovirus receptor 1
Synonyms SYG1; X3;
Species Homo sapiens
Ensembl Protein ENSP00000356562
InnateDB Gene IDBG-105178 (XPR1)
Protein Structure
UniProt Annotation
Function May function in G-protein coupled signal transduction (By similarity). Potential receptor for xenotropic and polytropic murine leukemia retroviruses. {ECO:0000250, ECO:0000269PubMed:9988277, ECO:0000269PubMed:9990033}.
Subcellular Localization Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Widely expressed. Detected in spleen, lymph node, thymus, leukocytes, bone marrow, heart, kidney, pancreas and skeletal muscle. {ECO:0000269PubMed:9927670, ECO:0000269PubMed:9990033}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0009615 response to virus
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004331 SPX, N-terminal
IPR004342 EXS, C-terminal
PFAM PF03105
PF03124
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBH6
PhosphoSite PhosphoSite-Q9UBH6
TrEMBL A0A024R911
UniProt Splice Variant
Entrez Gene 9213
UniGene Hs.623603
RefSeq NP_004727
HUGO HGNC:12827
OMIM 605237
CCDS CCDS1340
HPRD 05574
IMGT
EMBL AF089744 AF099082 AF115389 AL133058 AL137583 AL162431 AL358434 AL590085 BC041142 CH471067
GenPept AAD08928 AAD10196 AAD17211 AAH41142 CAB61383 CAB70825 CAH70457 CAH70458 CAH74089 CAH74090 CAH74113 CAH74114 EAW91086 EAW91087

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca