InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC10A1

Summary

InnateDB Protein

IDBP-10521.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC10A1

Protein Name

solute carrier family 10 (sodium/bile acid cotransporter family), member 1

Synonyms

NTCP;

Species

Homo sapiens

Ensembl Protein

ENSP00000216540

InnateDB Gene

IDBG-10519 (SLC10A1)

Protein Structure

UniProt Annotation

Function

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008508	bile acid:sodium symporter activity
GO:0015125	bile acid transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0006814	sodium ion transport
GO:0008206	bile acid metabolic process
GO:0015711	organic anion transport
GO:0015721	bile acid and bile salt transport
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane