InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAMC2

Summary

InnateDB Protein

IDBP-105295.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAMC2

Protein Name

laminin, gamma 2

Synonyms

B2T; BM600; CSF; EBR2; EBR2A; LAMB2T; LAMNB2;

Species

Homo sapiens

Ensembl Protein

ENSP00000264144

InnateDB Gene

IDBG-105293 (LAMC2)

Protein Structure

UniProt Annotation

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell- scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells. {ECO:0000269PubMed:8265624}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Disease Associations

Epidermolysis bullosa, junctional, Herlitz type (H-JEB) [MIM:226700]: An infantile and lethal form of junctional epidermolysis bullosa, a group of blistering skin diseases characterized by tissue separation which occurs within the dermo- epidermal basement In the Herlitz type, death occurs usually within the first six months of life. Occasionally, children survive to teens. It is marked by bullous lesions at birth and extensive denudation of skin and mucous membranes that may be hemorrhagic. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

The large variant is expressed only in specific epithelial cells of embryonic and neonatal tissues. In 17-week old embryo the small variant is found in cerebral cortex, lung, and distal tubes of kidney, but not in epithelia except for distal tubuli.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008201	heparin binding

Biological Process

GO:0007155	cell adhesion
GO:0008544	epidermis development
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0031581	hemidesmosome assembly
GO:0034329	cell junction assembly

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005607	laminin-2 complex
GO:0005610	laminin-5 complex
GO:0005615	extracellular space
GO:0005938	cell cortex
GO:0016020	membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000034 Laminin B type IV
IPR000742 Epidermal growth factor-like domain
IPR002049 EGF-like, laminin
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR018031 Laminin B, subgroup

PFAM

PF00052
PF00008
PF00053

PRINTS

PIRSF

SMART

SM00181
SM00180
SM00281

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13753