InnateDB Protein
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IDBP-105298.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NMNAT2
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Protein Name
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nicotinamide nucleotide adenylyltransferase 2
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Synonyms
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C1orf15; PNAT2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000287713
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InnateDB Gene
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IDBG-105296 (NMNAT2)
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Protein Structure
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Function |
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). {ECO:0000269PubMed:16118205, ECO:0000269PubMed:17402747}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:16118205}. Golgi apparatus {ECO:0000269PubMed:16118205}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans. {ECO:0000269PubMed:12359228, ECO:0000269PubMed:14516279, ECO:0000269PubMed:16118205}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004821
Cytidyltransferase-like domain
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PFAM |
PF01467
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BZQ4
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PhosphoSite |
PhosphoSite-Q9BZQ4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
23057
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UniGene |
Hs.497123
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RefSeq |
NP_055854
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HUGO |
HGNC:16789
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OMIM |
608701
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CCDS |
CCDS1353
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HPRD |
09786
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IMGT |
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EMBL |
AB007948
AF288395
AL354953
AL356981
AL449223
BC020998
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GenPept |
AAG60615
AAH20998
BAA32324
CAH70979
CAH70982
CAI15467
CAI15468
CAI16624
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