InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NMNAT2

Summary

InnateDB Protein

IDBP-105300.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NMNAT2

Protein Name

nicotinamide nucleotide adenylyltransferase 2

Synonyms

C1orf15; PNAT2;

Species

Homo sapiens

Ensembl Protein

ENSP00000294868

InnateDB Gene

IDBG-105296 (NMNAT2)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). {ECO:0000269PubMed:16118205, ECO:0000269PubMed:17402747}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:16118205}. Golgi apparatus {ECO:0000269PubMed:16118205}.

Disease Associations

Tissue Specificity

Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans. {ECO:0000269PubMed:12359228, ECO:0000269PubMed:14516279, ECO:0000269PubMed:16118205}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity
GO:0003824	catalytic activity
GO:0004515	nicotinate-nucleotide adenylyltransferase activity
GO:0005524	ATP binding

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0009058	biosynthetic process
GO:0009435	NAD biosynthetic process
GO:0019674	NAD metabolic process
GO:0044281	small molecule metabolic process