InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF2

Summary

InnateDB Protein

IDBP-105371.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF2

Protein Name

ring finger protein 2

Synonyms

BAP-1; BAP1; DING; HIPI3; RING1B; RING2;

Species

Homo sapiens

Ensembl Protein

ENSP00000356480

InnateDB Gene

IDBG-105369 (RNF2)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes. {ECO:0000269PubMed:11513855, ECO:0000269PubMed:15386022, ECO:0000269PubMed:16359901, ECO:0000269PubMed:16714294, ECO:0000269PubMed:20696397}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:21282530}. Chromosome {ECO:0000250}. Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 766 experimentally validated interaction(s) in this database.
They are also associated with 121 interaction(s) predicted by orthology.

Experimentally validated
Total	766 [view]
Protein-Protein	766 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	121 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding
GO:0071535	RING-like zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000278	mitotic cell cycle
GO:0001702	gastrulation with mouth forming second
GO:0006351	transcription, DNA-templated
GO:0009948	anterior/posterior axis specification
GO:0016574	histone ubiquitination
GO:0035518	histone H2A monoubiquitination
GO:0036353	histone H2A-K119 monoubiquitination

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0000791	euchromatin
GO:0000792	heterochromatin
GO:0001739	sex chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016604	nuclear body
GO:0031519	PcG protein complex
GO:0035102	PRC1 complex
GO:0071339	MLL1 complex