InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IVNS1ABP

Summary

InnateDB Protein

IDBP-105386.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IVNS1ABP

Protein Name

influenza virus NS1A binding protein

Synonyms

FLARA3; HSPC068; KLHL39; ND1; NS-1; NS1-BP; NS1BP;

Species

Homo sapiens

Ensembl Protein

ENSP00000356468

InnateDB Gene

IDBG-105384 (IVNS1ABP)

Protein Structure

UniProt Annotation

Function

Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. {ECO:0000250, ECO:0000269PubMed:16582008}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9696811}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:9696811}. Nucleus, nucleoplasm {ECO:0000269PubMed:9696811}. Note=Associated with actin filaments (By similarity). Localization related to speckle domains which correspond to interchromatin granules and are enriched in factors involved in pre-mRNA splicing. Following influenza A virus infection, redistribution from speckles to a more diffuse distribution in the nucleoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	60 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006383	transcription from RNA polymerase III promoter
GO:0008380	RNA splicing
GO:0009615	response to virus
GO:0016032	viral process
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type

PFAM

PF01344
PF07646
PF07707
PF00651

PRINTS

PIRSF

PIRSF037037

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt