Version 5.4
| Homo sapiens Protein: IVNS1ABP | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Protein | IDBP-105388.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | IVNS1ABP | ||||||||||||||||||||||
| Protein Name | influenza virus NS1A binding protein | ||||||||||||||||||||||
| Synonyms | FLARA3; HSPC068; KLHL39; ND1; NS-1; NS1-BP; NS1BP; | ||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||
| Ensembl Protein | ENSP00000356467 | ||||||||||||||||||||||
| InnateDB Gene | IDBG-105384 (IVNS1ABP) | ||||||||||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||||||||||
| Function | Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. {ECO:0000250, ECO:0000269PubMed:16582008}. | ||||||||||||||||||||||
| Subcellular Localization | Cytoplasm {ECO:0000269PubMed:9696811}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:9696811}. Nucleus, nucleoplasm {ECO:0000269PubMed:9696811}. Note=Associated with actin filaments (By similarity). Localization related to speckle domains which correspond to interchromatin granules and are enriched in factors involved in pre-mRNA splicing. Following influenza A virus infection, redistribution from speckles to a more diffuse distribution in the nucleoplasm. {ECO:0000250}. | ||||||||||||||||||||||
| Disease Associations | |||||||||||||||||||||||
| Tissue Specificity | |||||||||||||||||||||||
| Comments | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||||||||||
| PDB ID | |||||||||||||||||||||||
| InterPro |
IPR000210
BTB/POZ-like IPR011333 BTB/POZ fold IPR013069 BTB/POZ |
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| PFAM |
PF00651
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| PRINTS | |||||||||||||||||||||||
| PIRSF | |||||||||||||||||||||||
| SMART |
SM00225
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| TIGRFAMs | |||||||||||||||||||||||
| Post-translational Modifications | |||||||||||||||||||||||
| Modification | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| PhosphoSite | PhosphoSite-Q9Y6Y0 | ||||||||||||||||||||||
| TrEMBL | X6R674 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 10625 | ||||||||||||||||||||||
| UniGene | Hs.604920 | ||||||||||||||||||||||
| RefSeq | |||||||||||||||||||||||
| HUGO | HGNC:16951 | ||||||||||||||||||||||
| OMIM | 609209 | ||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||
| HPRD | 10004 | ||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | AL078644 AL356273 | ||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||