InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGS18

Summary

InnateDB Protein

IDBP-105442.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS18

Protein Name

regulator of G-protein signaling 18

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356430

InnateDB Gene

IDBG-105440 (RGS18)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha- 2, G(i) alpha-3 and G(q) alpha. {ECO:0000269PubMed:11042171, ECO:0000269PubMed:11955952}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in peripheral leukocytes, bone marrow, platelet, spleen and fetal liver. {ECO:0000269PubMed:11042171, ECO:0000269PubMed:11955952}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity