Version 5.4
Homo sapiens Protein: KCNT2
Summary
InnateDB Protein IDBP-105503.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNT2
Protein Name potassium channel, subfamily T, member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000294725
InnateDB Gene IDBG-105497 (KCNT2)
Protein Structure
UniProt Annotation
Function Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. {ECO:0000250, ECO:0000269PubMed:14684870, ECO:0000269PubMed:16687497}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005249 voltage-gated potassium channel activity
GO:0005524 ATP binding
GO:0015269 calcium-activated potassium channel activity
Biological Process
GO:0006813 potassium ion transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR003929 Potassium channel, calcium-activated, BK, alpha subunit
IPR013099 Two pore domain potassium channel domain
PFAM PF03493
PF07885
PRINTS PR01449
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UVM3
PhosphoSite PhosphoSite-Q6UVM3
TrEMBL A9LNM6
UniProt Splice Variant
Entrez Gene 343450
UniGene Hs.657046
RefSeq NP_940905
HUGO HGNC:18866
OMIM 610044
CCDS CCDS1384
HPRD 11584
IMGT
EMBL AK131498 AL138931 AL139137 AL358853 AL591604 AY359444 BC103948 BC103949 BC103950 BX647852 EU251076
GenPept AAI03949 AAI03950 AAI03951 AAR06170 ABX11496 BAD18642 CAH71957 CAH71958 CAH72932 CAH72933 CAI15623 CAI15624 CAI16091 CAI16092 CAI46099

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca