Version 5.4
Homo sapiens Protein: CFHR1
Summary
InnateDB Protein IDBP-105522.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CFHR1
Protein Name complement factor H-related 1
Synonyms CFHL; CFHL1; CFHL1P; CFHR1P; FHR1; H36-1; H36-2; HFL1; HFL2;
Species Homo sapiens
Ensembl Protein ENSP00000314299
InnateDB Gene IDBG-409281 (CFHR1)
Protein Structure
UniProt Annotation
Function Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism. {ECO:0000269PubMed:23487775}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed by the liver and secreted in plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006956 complement activation
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR000436 Sushi/SCR/CCP
PFAM PF00084
PRINTS
PIRSF
SMART SM00032
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q03591
PhosphoSite PhosphoSite-
TrEMBL Q6LBM9
UniProt Splice Variant
Entrez Gene 3078
UniGene Hs.575869
RefSeq NP_002104
HUGO HGNC:4888
OMIM 134371
CCDS CCDS1386
HPRD 00602
IMGT
EMBL AK290830 AL049741 BC016755 BC107771 M65292 M65293 X56209 X56210
GenPept AAA35946 AAA35947 AAH16755 AAI07772 BAF83519 CAA39666 CAA39667 CAB53063

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca