Version 5.4
Homo sapiens Protein: F13B
Summary
InnateDB Protein IDBP-105542.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F13B
Protein Name coagulation factor XIII, B polypeptide
Synonyms FXIIIB;
Species Homo sapiens
Ensembl Protein ENSP00000356382
InnateDB Gene IDBG-105540 (F13B)
Protein Structure
UniProt Annotation
Function The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin.
Subcellular Localization Secreted.
Disease Associations Factor XIII subunit B deficiency (FA13BD) [MIM:613235]: An autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. {ECO:0000269PubMed:11313256, ECO:0000269PubMed:8324218}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007596 blood coagulation
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR000436 Sushi/SCR/CCP
PFAM PF00084
PRINTS
PIRSF
SMART SM00032
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P05160
PhosphoSite PhosphoSite-P05160
TrEMBL
UniProt Splice Variant
Entrez Gene 2165
UniGene Hs.435782
RefSeq NP_001985
HUGO HGNC:3534
OMIM 134580
CCDS CCDS1388
HPRD 00605
IMGT
EMBL AK290560 AL353809 AY692223 M14057 M64554 X51823
GenPept AAA51821 AAA88042 AAT85802 BAF83249 CAA36123 CAH72549

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca