InnateDB Protein
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IDBP-105768.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PHLDA3
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Protein Name
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pleckstrin homology-like domain, family A, member 3
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Synonyms
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TIH1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000356280
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InnateDB Gene
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IDBG-105766 (PHLDA3)
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Protein Structure
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Function |
p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. {ECO:0000269PubMed:19203586}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:19203586}. Membrane {ECO:0000269PubMed:19203586}; Peripheral membrane protein {ECO:0000269PubMed:19203586}.
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Disease Associations |
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Tissue Specificity |
Widely expressed with lowest expression in liver and spleen. {ECO:0000269PubMed:10594239}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
26
[view]
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Protein-Protein |
26
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005546
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phosphatidylinositol-4,5-bisphosphate binding
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GO:0005547
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phosphatidylinositol-3,4,5-trisphosphate binding
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GO:0010314
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phosphatidylinositol-5-phosphate binding
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GO:0032266
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phosphatidylinositol-3-phosphate binding
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GO:0043325
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phosphatidylinositol-3,4-bisphosphate binding
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GO:0080025
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phosphatidylinositol-3,5-bisphosphate binding
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Biological Process |
GO:0009653
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anatomical structure morphogenesis
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GO:0042771
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intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
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GO:0043065
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positive regulation of apoptotic process
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GO:0051898
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negative regulation of protein kinase B signaling
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Cellular Component |
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PDB ID |
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InterPro |
IPR001849
Pleckstrin homology domain
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PFAM |
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y5J5
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PhosphoSite |
PhosphoSite-Q9Y5J5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
23612
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UniGene |
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RefSeq |
NP_036528
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HUGO |
HGNC:8934
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OMIM |
607054
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CCDS |
CCDS1412
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HPRD |
09519
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IMGT |
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EMBL |
AF151100
AK075179
AK222644
AK312115
BC014390
BC068273
CH471067
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GenPept |
AAD42081
AAH14390
AAH68273
BAC11454
BAD96364
BAG35051
EAW91369
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