InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNPEP

Summary

InnateDB Protein

IDBP-105807.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNPEP

Protein Name

arginyl aminopeptidase (aminopeptidase B)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000295640

InnateDB Gene

IDBG-105805 (RNPEP)

Protein Structure

UniProt Annotation

Function

Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(- 1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0004301	epoxide hydrolase activity
GO:0005488	binding
GO:0008235	metalloexopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0019370	leukotriene biosynthetic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal
IPR015211 Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal
IPR016024 Armadillo-type fold

PFAM

PF01433
PF09127

PRINTS

PR00756

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9H4A4