InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPR37L1

Summary

InnateDB Protein

IDBP-105821.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR37L1

Protein Name

G protein-coupled receptor 37 like 1

Synonyms

ET(B)R-LP-2; ETBR-LP-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000356251

InnateDB Gene

IDBG-105819 (GPR37L1)

Protein Structure

UniProt Annotation

Function

Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade. {ECO:0000269PubMed:23690594}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in the central nervous system.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0008150	biological_process
GO:0021940	positive regulation of cerebellar granule cell precursor proliferation
GO:0045665	negative regulation of neuron differentiation
GO:0045879	negative regulation of smoothened signaling pathway
GO:0048712	negative regulation of astrocyte differentiation