InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYB5R1

Summary

InnateDB Protein

IDBP-105900.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYB5R1

Protein Name

cytochrome b5 reductase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356218

InnateDB Gene

IDBG-105898 (CYB5R1)

Protein Structure

UniProt Annotation

Function

NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:10611283}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0016491	oxidoreductase activity

Biological Process

GO:0008150	biological_process
GO:0016126	sterol biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001221 Phenol hydroxylase reductase
IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
IPR001834 NADH:cytochrome b5 reductase (CBR)
IPR008333 Oxidoreductase, FAD-binding domain
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF00175
PF00970

PRINTS

PR00410
PR00371
PR00406

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UHQ9