InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP2B4

Summary

InnateDB Protein

IDBP-105963.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP2B4

Protein Name

ATPase, Ca++ transporting, plasma membrane 4

Synonyms

ATP2B2; MXRA1; PMCA4; PMCA4b; PMCA4x;

Species

Homo sapiens

Ensembl Protein

ENSP00000350310

InnateDB Gene

IDBG-105961 (ATP2B4)

Protein Structure

UniProt Annotation

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform XB is the most abundant isoform and is expressed ubiquitously. Isoforms containing segment Z have only been detected in heart, while isoforms containing segment a have been found in heart, stomach and brain cortex.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0017080	sodium channel regulator activity
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding
GO:0097110	scaffold protein binding

Biological Process

GO:0006810	transport
GO:0006812	cation transport
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation
GO:1902305	regulation of sodium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR006408 Calcium-transporting P-type ATPase, subfamily IIB
IPR008250 P-type ATPase, A domain
IPR022141 Calcium transporting P-type ATPase, C-terminal, plasma membrane
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM