InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP1R15B

Summary

InnateDB Protein

IDBP-106046.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1R15B

Protein Name

protein phosphatase 1, regulatory subunit 15B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356156

InnateDB Gene

IDBG-106044 (PPP1R15B)

Protein Structure

UniProt Annotation

Function

Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding

Biological Process

GO:0006417	regulation of translation
GO:0006979	response to oxidative stress
GO:0006983	ER overload response
GO:0016311	dephosphorylation
GO:0034976	response to endoplasmic reticulum stress
GO:0042542	response to hydrogen peroxide

Cellular Component

GO:0000164

protein phosphatase type 1 complex

Protein Structure and Domains

PDB ID

InterPro

IPR019512 Protein phosphatase 1, regulatory subunit 15B, N-terminal
IPR019523 Protein phosphatase 1, regulatory subunit 15A/B, C-terminal

PFAM

PF10472
PF10488

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5SWA1

PhosphoSite

PhosphoSite-Q5SWA1

TrEMBL

B7Z9X7

UniProt Splice Variant

Entrez Gene

84919

UniGene

Hs.707708

RefSeq

NP_116222

HUGO

HGNC:14951

OMIM

613257

CCDS

CCDS1445

HPRD

17892

IMGT

EMBL

AK027650 AK222877 AK316092 AL606489 AL833746 BC065280

GenPept

AAH65280 BAB55266 BAD96597 BAH14463 CAH56240 CAI16570