Homo sapiens Protein: DSTYK
Summary
InnateDB Protein IDBP-106108.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DSTYK
Protein Name dual serine/threonine and tyrosine protein kinase
Synonyms CAKUT1; DustyPK; RIP5; RIPK5;
Species Homo sapiens
Ensembl Protein ENSP00000356130
InnateDB Gene IDBG-106106 (DSTYK)
Protein Structure
UniProt Annotation
Function May induce both caspase-dependent apoptosis and caspase- independent cell death. {ECO:0000269PubMed:15178406}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17123648}.
Disease Associations
Tissue Specificity Predominantly expressed in skeletal muscle and testis. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. {ECO:0000269PubMed:15178406, ECO:0000269PubMed:17123648}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6XUX3
PhosphoSite PhosphoSite-Q6XUX3
TrEMBL
UniProt Splice Variant
Entrez Gene 25778
UniGene Hs.6874
RefSeq NP_056190
HUGO HGNC:29043
OMIM 612666
CCDS CCDS1451
HPRD 11495
IMGT
EMBL AB007941 AC093422 AF068286 AY208850 AY429674 BC048204 BC053627 BC060870 BC072406 BC117411 BC143603
GenPept AAF65505 AAH48204 AAH53627 AAH60870 AAH72406 AAI17412 AAI43604 AAP42418 AAS55390 BAA32317