Version 5.4
Homo sapiens Protein: SLC41A1
Summary
InnateDB Protein IDBP-106180.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC41A1
Protein Name solute carrier family 41, member 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000356105
InnateDB Gene IDBG-106178 (SLC41A1)
Protein Structure
UniProt Annotation
Function Acts as a magnesium transporter that is responsive to magnesium balance. {ECO:0000269PubMed:15713785}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen. {ECO:0000269PubMed:12810078}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008324 cation transmembrane transporter activity
Biological Process
GO:0006812 cation transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR006667 SLC41 divalent cation transporters, integral membrane domain
PFAM PF01769
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IVJ1
PhosphoSite PhosphoSite-Q8IVJ1
TrEMBL B2RMP2
UniProt Splice Variant
Entrez Gene 254428
UniGene Hs.20274
RefSeq NP_776253
HUGO HGNC:19429
OMIM 610801
CCDS CCDS30988
HPRD 15388
IMGT
EMBL AJ514402 AK128069 AL831974 AL832001 AL832362 BC136303 BX641054 BX648979 CH471067
GenPept AAI36304 BAG54625 CAD58404 CAE46028 CAH56135 CAH56211 CAH56213 CAH56217 EAW91582 EAW91583

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca