Version 5.4
Homo sapiens Protein: FAM72A
Summary
InnateDB Protein IDBP-106205.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM72A
Protein Name family with sequence similarity 72, member A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000356096
InnateDB Gene IDBG-106199 (FAM72A)
Protein Structure
UniProt Annotation
Function May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation. {ECO:0000269PubMed:21317926}.
Subcellular Localization Cytoplasm. Mitochondrion. Note=A V5 epitope- tagged construct has been shown to localize to the nucleus (PubMed:18676834). 5-7% of total FAM72A is associated with mitochondria around the nucleus in HEK293 cells (PubMed:21317926). {ECO:0000269PubMed:18676834, ECO:0000269PubMed:21317926}.
Disease Associations
Tissue Specificity May be up-regulated in malignant colon cancers, compared to normal colon and colon adenomas. Expression is also elevated in other common cancer types, including breast, lung, uterus, and ovary. {ECO:0000269PubMed:18676834}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5TYM5
PhosphoSite PhosphoSite-
TrEMBL U3KPW2
UniProt Splice Variant
Entrez Gene 729533
UniGene Hs.661924
RefSeq NP_001116640
HUGO HGNC:24044
OMIM 614710
CCDS CCDS73016
HPRD
IMGT
EMBL BC035696 BC146978 BC146992 CR407567
GenPept AAH35696 AAI46979 AAI46993 CAH72365 CAH72366

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca