InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL20

Summary

InnateDB Protein

IDBP-106280.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL20

Protein Name

interleukin 20

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000356065

InnateDB Gene

IDBG-106278 (IL20)

Protein Structure

UniProt Annotation

Function

Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3. {ECO:0000269PubMed:16511554}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endothelial cells (mainly in small vessels or capillaries), macrophages, and skeletal muscle. Isoform 2 was detected in the lung tissue only. {ECO:0000269PubMed:16908179}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0045517	interleukin-20 receptor binding
GO:0045518	interleukin-22 receptor binding

Biological Process

GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045606	positive regulation of epidermal cell differentiation
GO:0045618	positive regulation of keratinocyte differentiation
GO:0045672	positive regulation of osteoclast differentiation
GO:0050727	regulation of inflammatory response