InnateDB Protein
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IDBP-106335.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CD55
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Protein Name
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CD55 molecule, decay accelerating factor for complement (Cromer blood group)
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Synonyms
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CR; CROM; DAF; TC;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000316333
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InnateDB Gene
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IDBG-106331 (CD55)
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Protein Structure
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Function |
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. {ECO:0000269PubMed:7525274}.
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Subcellular Localization |
Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor.Isoform 3: Secreted {ECO:0000269PubMed:16503113}.Isoform 4: Secreted {ECO:0000269PubMed:16503113}.Isoform 5: Secreted {ECO:0000269PubMed:16503113}.Isoform 6: Cell membrane {ECO:0000305PubMed:16503113}; Lipid-anchor, GPI-anchor {ECO:0000305PubMed:16503113}.Isoform 7: Cell membrane {ECO:0000305PubMed:16503113}; Lipid-anchor, GPI-anchor {ECO:0000305PubMed:16503113}.
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Disease Associations |
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Tissue Specificity |
Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
27
[view]
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Protein-Protein |
25
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006958
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complement activation, classical pathway
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GO:0007204
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positive regulation of cytosolic calcium ion concentration
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GO:0009615
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response to virus
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GO:0030449
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regulation of complement activation
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GO:0031664
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regulation of lipopolysaccharide-mediated signaling pathway
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GO:0035743
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CD4-positive, alpha-beta T cell cytokine production
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GO:0045087
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innate immune response
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GO:0045730
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respiratory burst
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GO:0045916
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negative regulation of complement activation
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GO:2000516
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positive regulation of CD4-positive, alpha-beta T cell activation
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GO:2000563
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positive regulation of CD4-positive, alpha-beta T cell proliferation
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Cellular Component |
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PDB ID |
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InterPro |
IPR000436
Sushi/SCR/CCP
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PFAM |
PF00084
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PRINTS |
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PIRSF |
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SMART |
SM00032
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TIGRFAMs |
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Modification |
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SwissProt |
P08174
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PhosphoSite |
PhosphoSite-P08174
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TrEMBL |
Q76N74
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UniProt Splice Variant |
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Entrez Gene |
1604
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UniGene |
Hs.732565
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RefSeq |
NP_001287833
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HUGO |
HGNC:2665
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OMIM |
125240
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CCDS |
CCDS44307
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HPRD |
00500
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IMGT |
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EMBL |
AB003312
AB240566
AB240567
AB240568
AB240569
AB240570
AL391597
AL596218
AY851161
BC001288
BT007159
CH471100
M15799
M30142
M31516
M64356
M64653
S72858
U88576
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GenPept |
AAA52167
AAA52168
AAA52169
AAA52170
AAB48622
AAC60633
AAH01288
AAP35823
AAW29942
BAA22900
BAE97422
BAE97423
BAE97424
BAE97425
BAE97426
CAH72946
CAI16463
EAW93485
EAW93487
EAW93488
EAW93491
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