InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD55

Summary

InnateDB Protein

IDBP-106341.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD55

Protein Name

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

Synonyms

CR; CROM; DAF; TC;

Species

Homo sapiens

Ensembl Protein

ENSP00000356031

InnateDB Gene

IDBG-106331 (CD55)

Protein Structure

UniProt Annotation

Function

This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. {ECO:0000269PubMed:7525274}.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor.Isoform 3: Secreted {ECO:0000269PubMed:16503113}.Isoform 4: Secreted {ECO:0000269PubMed:16503113}.Isoform 5: Secreted {ECO:0000269PubMed:16503113}.Isoform 6: Cell membrane {ECO:0000305PubMed:16503113}; Lipid-anchor, GPI-anchor {ECO:0000305PubMed:16503113}.Isoform 7: Cell membrane {ECO:0000305PubMed:16503113}; Lipid-anchor, GPI-anchor {ECO:0000305PubMed:16503113}.

Disease Associations

Tissue Specificity

Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	25 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0005515	protein binding
GO:0008289	lipid binding

Biological Process

GO:0006958	complement activation, classical pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0009615	response to virus
GO:0030449	regulation of complement activation
GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway
GO:0035743	CD4-positive, alpha-beta T cell cytokine production
GO:0045087	innate immune response
GO:0045730	respiratory burst
GO:0045916	negative regulation of complement activation
GO:2000516	positive regulation of CD4-positive, alpha-beta T cell activation
GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0031225	anchored component of membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome