InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CR2

Summary

InnateDB Protein

IDBP-106351.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CR2

Protein Name

complement component (3d/Epstein Barr virus) receptor 2

Synonyms

C3DR; CD21; CR; CVID7; SLEB9;

Species

Homo sapiens

Ensembl Protein

ENSP00000356024

InnateDB Gene

IDBG-106349 (CR2)

Protein Structure

UniProt Annotation

Function

Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. {ECO:0000269PubMed:7753047}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Systemic lupus erythematosus 9 (SLEB9) [MIM:610927]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269PubMed:17360460}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Immunodeficiency, common variable, 7 (CVID7) [MIM:614699]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269PubMed:22035880}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	12 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001848	complement binding
GO:0003677	DNA binding
GO:0004872	receptor activity
GO:0004875	complement receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0002430	complement receptor mediated signaling pathway
GO:0006955	immune response
GO:0006958	complement activation, classical pathway
GO:0030183	B cell differentiation
GO:0042100	B cell proliferation
GO:0042113	B cell activation
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome