InnateDB Protein
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IDBP-106542.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPP2R5A
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Protein Name
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protein phosphatase 2, regulatory subunit B', alpha
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Synonyms
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B56A; PR61A;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000261461
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InnateDB Gene
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IDBG-106540 (PPP2R5A)
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Protein Structure
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Function |
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
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Subcellular Localization |
Cytoplasm. Nucleus. Chromosome, centromere. Note=From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase.
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Disease Associations |
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Tissue Specificity |
Widely expressed with the highest expression in heart and skeletal muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
41
[view]
|
Protein-Protein |
40
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0007165
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signal transduction
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GO:0035307
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positive regulation of protein dephosphorylation
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GO:0090005
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negative regulation of establishment of protein localization to plasma membrane
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GO:0090219
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negative regulation of lipid kinase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR002554
Protein phosphatase 2A, regulatory B subunit, B56
IPR016024
Armadillo-type fold
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PFAM |
PF01603
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PRINTS |
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PIRSF |
PIRSF028043
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q15172
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PhosphoSite |
PhosphoSite-Q15172
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5525
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UniGene |
Hs.743554
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RefSeq |
NP_006234
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HUGO |
HGNC:9309
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OMIM |
601643
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CCDS |
CCDS1503
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HPRD |
03384
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IMGT |
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EMBL |
AK302202
AK312530
AL360091
AL451060
BC022474
BC110883
CH471100
L42373
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GenPept |
AAC37601
AAH22474
AAI10884
BAG35429
BAH13648
CAH71821
CAH73229
EAW93392
EAW93393
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