InnateDB Protein
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IDBP-106548.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NENF
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Protein Name
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neudesin neurotrophic factor
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000355955
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InnateDB Gene
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IDBG-106546 (NENF)
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Protein Structure
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Function |
Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted, extracellular space {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
31
[view]
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Protein-Protein |
31
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001199
Cytochrome b5-like heme/steroid binding domain
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PFAM |
PF00173
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PRINTS |
PR00363
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UMX5
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PhosphoSite |
PhosphoSite-Q9UMX5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
29937
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UniGene |
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RefSeq |
NP_037481
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HUGO |
HGNC:30384
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OMIM |
611874
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CCDS |
CCDS1505
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HPRD |
11603
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IMGT |
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EMBL |
AB126219
AF173937
AK223135
AY762102
BC008823
CH471100
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GenPept |
AAD51419
AAH08823
AAX07829
BAD72063
BAD96855
EAW93389
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