InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BATF3

Summary

InnateDB Protein

IDBP-106574.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BATF3

Protein Name

basic leucine zipper transcription factor, ATF-like 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000243440

InnateDB Gene

IDBG-106572 (BATF3)

Protein Structure

UniProt Annotation

Function

AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens (By similarity). Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes. {ECO:0000250, ECO:0000269PubMed:10878360, ECO:0000269PubMed:12087103, ECO:0000269PubMed:15467742}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00978, ECO:0000269PubMed:12087103}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0009615	response to virus
GO:0043011	myeloid dendritic cell differentiation
GO:0097028	dendritic cell differentiation