InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HIBADH

Summary

InnateDB Protein

IDBP-10664.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HIBADH

Protein Name

3-hydroxyisobutyrate dehydrogenase

Synonyms

NS5ATP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000265395

InnateDB Gene

IDBG-10662 (HIBADH)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Detected in skin fibroblasts. {ECO:0000269PubMed:16466957}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity
GO:0008442	3-hydroxyisobutyrate dehydrogenase activity
GO:0051287	NAD binding

Biological Process

GO:0006098	pentose-phosphate shunt
GO:0006574	valine catabolic process
GO:0009083	branched-chain amino acid catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR011548 3-hydroxyisobutyrate dehydrogenase
IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal

PFAM

PF03446
PF02826
PF03807

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P31937

PhosphoSite