InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPN14

Summary

InnateDB Protein

IDBP-106647.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPN14

Protein Name

protein tyrosine phosphatase, non-receptor type 14

Synonyms

PEZ; PTP36;

Species

Homo sapiens

Ensembl Protein

ENSP00000355923

InnateDB Gene

IDBG-106645 (PTPN14)

Protein Structure

UniProt Annotation

Function

Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell- matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial- mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor. {ECO:0000269PubMed:10934049, ECO:0000269PubMed:12808048, ECO:0000269PubMed:17893246, ECO:0000269PubMed:20826270, ECO:0000269PubMed:22233626, ECO:0000269PubMed:22525271, ECO:0000269PubMed:22948661}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus. Note=Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.

Disease Associations

Choanal atresia and lymphedema (CHATLY) [MIM:613611]: A disease characterized by posterior choanal atresia and lymphedema. Additional features are a high-arched palate, hypoplastic nipples, and mild pectus excavatum. {ECO:0000269PubMed:20826270}. Note=The disease is caused by mutations affecting the gene represented in this entry. A homozygous deletion in PTPN14 predicted to result in frameshift and premature truncation, has been shown to be the cause of choanal atresia and lymphedema in one family.Note=Influence clinical severity of hereditary haemorragic telagiectasia (HHT).Note=Frequently mutated in a variety of human cancers.

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.

Experimentally validated
Total	42 [view]
Protein-Protein	42 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003712	transcription cofactor activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0030971	receptor tyrosine kinase binding

Biological Process

GO:0001946	lymphangiogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006470	protein dephosphorylation
GO:0008285	negative regulation of cell proliferation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0046825	regulation of protein export from nucleus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000299 FERM domain
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR014392 Protein-tyrosine phosphatase, non-receptor type-14, -21
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029021 Protein-tyrosine phosphatase-like
IPR029071 Ubiquitin-related domain

PFAM

PF00102
PF00782
PF09379
PF09380
PF00373

PRINTS

PR00700
PR00935

PIRSF

PIRSF000934

SMART

SM00194
SM00404
SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References