Homo sapiens Protein: LYPLAL1
Summary
InnateDB Protein IDBP-106719.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LYPLAL1
Protein Name lysophospholipase-like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355894
InnateDB Gene IDBG-106715 (LYPLAL1)
Protein Structure
UniProt Annotation
Function Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site. {ECO:0000269PubMed:22052940, ECO:0000269PubMed:22399288}.
Subcellular Localization Isoform 1: Cytoplasm, cytosol {ECO:0000269PubMed:22399288}.Isoform 2: Cytoplasm, cytosol {ECO:0000269PubMed:22399288}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004622 lysophospholipase activity
GO:0016787 hydrolase activity
Biological Process
GO:0008150 biological_process
GO:0008152 metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000801 Putative esterase
IPR002925 Dienelactone hydrolase
IPR003140 Phospholipase/carboxylesterase/thioesterase
IPR013094 Alpha/beta hydrolase fold-3
IPR029058 Alpha/Beta hydrolase fold
PFAM PF00756
PF01738
PF02230
PF07859
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5VWZ2
PhosphoSite PhosphoSite-Q5VWZ2
TrEMBL
UniProt Splice Variant
Entrez Gene 127018
UniGene Hs.694562
RefSeq NP_001287699
HUGO HGNC:20440
OMIM
CCDS CCDS73032
HPRD 14335
IMGT
EMBL AK291542 AL360093 AY341430 BC016711
GenPept AAH16711 AAQ17077 BAF84231 CAH70459 CAH70460